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KMID : 0384620070180010020
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Korean Journal of Medical Physics
2007 Volume.18 No. 1 p.20 ~ p.26
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Spatiotemporal Analysis of Retinal Waveform using Independent Component Analysis in Normal and rd/rd Mouse
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Ye Jang-Hee
Kim Tae-Seung
Goo Yong-Sook
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Abstract
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It is expected that synaptic construction and electrical characteristics In degenerate retina might be different from those In normal retina. Therefore, we analyzed the retinal waveform recorded with multielectrode array in normal and degenerate retina using principal component analysis (PCA) and Independent component analysis (ICA) and compared the results. PCA Is a well established method for retinal waveform while ICA has not tried for retinal waveform analysis. We programmed ICA toolbox for spatiotemporal analysis of retinal waveform. In normal mouse, the MEA spatial map shows a single hot spot perfectly matched with PCA-derived ON or OFF ganglion cell response. However In rd/rd mouse, the MEA spatial map shows numerous hot and cold spots whose underlying interactions and mechanisms need further Investigation for better understanding.
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KEYWORD
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Degenerate retina, Multielectrode array, Principal component analysis, Independent component analysis, Retinal waveform
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